really the only time youll have to worry is if youre rushing to beat a closure, cause that's when the roads are at their worst and everyone is in a hurry to get where theyre going before 70 gets closed at the tunnel or at Vail pass. once it's cleared and reopened it's usually pretty good for a while unless the storm is a particularly nasty one.
most of the climbs are pretty gradual so no problems there, what has always scared me is the descents. the two spots im thinking of are when youre descending down from the tunnel to silverthorne and when you're descending the west side of vail pass...those two can be reaaaally really scary if it's dark and there's a bad storm going on. i always worry when there's a couple inches of hardpack built up on the road, even with ABS and 4x4 your wheels can lock for a split second and get you going sideways into a wall or something. it doesnt take much to fuck you up when youre going down a steady grade like that at 40+ mph. fortunately you probably wont be going to vail much, as i consider that one to be the worst of the two by a pretty wide margin, the descent after the tunnel is sketchy but not AS sketchy.
"Just ahead, over the rolling wheatfields all golden beneath the distant snows of Estes, I'd be seeing old Denver at last. I pictured myself in a Denver bar that night, with all the gang, and in their eyes I would be strange and ragged like the Prophet who has walked across the land to bring the dark Word, and the only Word I had was 'Wow!'"