A test was carried out on the substance that showed that, when ingested in large amounts, nutmeg takes on a similar chemical make-up to MDMA (ecstasy). However, use of nutmeg as a recreational drug is unpopular due to its unpleasant taste and its side effects, including dizziness, flushes, dry mouth, accelerated heartbeat, temporary constipation, difficulty in urination, nausea, and panic. A user will not experience a peak until approximately six hours after ingestion, and effects can linger for up to three days afterwards.
A risk in any large-quantity (over 25 g, ~5 teaspoons) ingestion of nutmeg is the onset of 'nutmeg poisoning', an acute psychiatric disorder marked by thought disorder, a sense of impending doom/death, and agitation. Some cases have resulted in hospitalization.
Fatal doses in children are significantly lower, with approximately 15g being sufficient to cause one of only two recorded nutmeg toxicity deaths, in an eight year old child.BMJ.Nutmeg is an abortifacient, and as such any significant doses should be avoided by pregnant women.BMJ