im right handed so the bottom right corner is easiest for my thumb, therefore i put my most used apps there. Classics like Maps, Weather, Camera get the other corners.
just added songza and TuneIn to my home screen to replace Streak for the Cash and Remote app, hoping it works out.
my second screen is less-used apps in folders. usually have an 8th folder for 'skiing' but i deleted it to save memory in this off season.
I knows mines pretty standard, so lets see yours. maybe we can share some good ideas.