CRISPER and genetic engineering

i see no ethical issue with getting rid of every genetic disease ever

Blindsurferi see no ethical issue with getting rid of every genetic disease ever

I have no issue with that either. But engineering people, while it could be good (making them healthier, stronger and such) it could also be bad (engineering people for certain jobs and certain careers)

If you've seen gattaca you know what I'm talking about

LonelyI have no issue with that either. But engineering people, while it could be good (making them healthier, stronger and such) it could also be bad (engineering people for certain jobs and certain careers)

If you've seen gattaca you know what I'm talking about

seen gattaca. i'm about to blow your mind tho. America has already genetically engineered the perfect black person. wana know why so many american black guys are huge and naturally athletic? think back to the slave days. slave masters only wanted the biggest, strongest, and fittest slaves to work the fields. results? big strong slaves continue to breed and survive, and their progeny inherits their genes, thus being naturally big and strong.

basically what i'm saying is that a country that was built wholly upon human slavery should have no issue with fucking with people's genes a little

Dude, every woman could have perfect boobs. That would be tits!

Blindsurferseen gattaca. i'm about to blow your mind tho. America has already genetically engineered the perfect black person. wana know why so many american black guys are huge and naturally athletic? think back to the slave days. slave masters only wanted the biggest, strongest, and fittest slaves to work the fields. results? big strong slaves continue to breed and survive, and their progeny inherits their genes, thus being naturally big and strong.

basically what i'm saying is that a country that was built wholly upon human slavery should have no issue with fucking with people's genes a little

I get where you're coming from but I don't necessarily agree with the logic that since we fucked up before we should have no problem doing it again. And again, No issue with some altering preventing disease. I'm saying to look further down the road where you are altered before birth to perform a certain task with no choice.

LonelySo I read an article the other day about how we have begun to use crisper, which more or less will allow us to alter genes. Previously we had only been able to change the environment, not the gene itself. This is important because we can alter misformed genes.

Will this allow us to make perfect people? And if so is that even ethical?

In today's day and age where organs are beginning to be 3d printed I would not be surprised if the next generation will live over 100.

Discuss.

Millennials are projected to live 100+ years on the norm. People that will live to 150 are already alive.

My english muffin was CRISPER than normal this morning. My CRISP array however is well... I don't have one. The crispr array is a string of dna in bacteria that needs a bunch of accessory proteins to work. The nuclease one is what we make use of.

Currently the primary use of the crispr nuclease is just to make double strand breaks in really specific places. OR you can use two to chop out a whole section of dna. If you want to change stuff you have to provide a repair template so you can do homology directed repair instead of non-homologous end joining. crispr is great for making knockout mice.

you can use it to change stuff like this for example. it's even in stem cells http://www.cell.com/cell-stem-cell/abstract/S1934-5909%2813%2900493-1

a_pla5tic_bagMy english muffin was CRISPER than normal this morning. My CRISP array however is well... I don't have one. The crispr array is a string of dna in bacteria that needs a bunch of accessory proteins to work. The nuclease one is what we make use of.

Currently the primary use of the crispr nuclease is just to make double strand breaks in really specific places. OR you can use two to chop out a whole section of dna. If you want to change stuff you have to provide a repair template so you can do homology directed repair instead of non-homologous end joining. crispr is great for making knockout mice.

you can use it to change stuff like this for example. it's even in stem cells http://www.cell.com/cell-stem-cell/abstract/S1934-5909%2813%2900493-1

Read the article quickly, although not thoroughly. Thanks for extra info.

That's a paper out of a scientific journal not an article. You need to go through your school to read it if you want but you probably have to be some kind of biologist or something to understand it.

They fixed a cystic fibrosis gene basically.

Reality is now Gattaca

a_pla5tic_bagThat's a paper out of a scientific journal not an article. You need to go through your school to read it if you want but you probably have to be some kind of biologist or something to understand it.

They fixed a cystic fibrosis gene basically.

Nah I was talking about the original article I read haha. But yeah I've gone through my college and have been reading up on it. I've gone through the farthest levels of math and physics that I can....but right now I can't get much science (biology related at least) until I get up to m tech at the end of this year. It's interesting stuff

I have a genetic disease called HCM (it's also hereditary). It'd be cool to have it fixed.

we could use it to fix skiierman's autism

AgitatedHiatusI have a genetic disease called HCM (it's also hereditary). It'd be cool to have it fixed.

That's the other problem. You cant just go about changing stuff in people and expect it to work. If you have a genetic condition that causes developmental issues then you'd need to tackle those before they develop i.e. when you're like 8 cells large. Otherwise you need to hope your issue is in a tissue that has rapidly dividing stem cells like intestines.

If by HCM you mean the heart issue, then according to wikipedia, mutants of sarcomere (things that makes up muscles) proteins are to blame. Hypertrophy is probably because since muscles don't function as well, you need more of it to get normal cardiac output. I don't know if fixing those proteins would allow the heart to shrink, maybe it would. It's certainly worth a shot in mice.

Here's the real utility of crispr, you could have your genome sequenced, find out the exact mutation you have and make the same exact mutation in some mice, let those mice develop from embryos, then attempt to use crispr and provide a repair template and fix the gene at various stages of life and see what happens. your biggest problem is delivering a crispr system and template to the heart. I guess a virus is the way to go but i'm not sure on that. That actually sounds pretty exciting I hope someone tries it.

a_pla5tic_bagThat's the other problem. You cant just go about changing stuff in people and expect it to work. If you have a genetic condition that causes developmental issues then you'd need to tackle those before they develop i.e. when you're like 8 cells large. Otherwise you need to hope your issue is in a tissue that has rapidly dividing stem cells like intestines.

If by HCM you mean the heart issue, then according to wikipedia, mutants of sarcomere (things that makes up muscles) proteins are to blame. Hypertrophy is probably because since muscles don't function as well, you need more of it to get normal cardiac output. I don't know if fixing those proteins would allow the heart to shrink, maybe it would. It's certainly worth a shot in mice.

Here's the real utility of crispr, you could have your genome sequenced, find out the exact mutation you have and make the same exact mutation in some mice, let those mice develop from embryos, then attempt to use crispr and provide a repair template and fix the gene at various stages of life and see what happens. your biggest problem is delivering a crispr system and template to the heart. I guess a virus is the way to go but i'm not sure on that. That actually sounds pretty exciting I hope someone tries it.

Yeah I do mean the heart issue. I've been researching potential cures lately (I can be an optimist) but I've never come across this. I hope some doctor tries it. Do you think that it would react differently in each person? (The genetic changing)

AgitatedHiatusI hope some doctor tries it. Do you think that it would react differently in each person? (The genetic changing)

These are the kind of things you need years of research to figure out. Plus even if the science is figured out and it could work perfectly you'd have to do clinical trials and I imagine with something like that would take a really long time. Plus even if all that does work perfectly, you'd have to convince all the people concerned about ethics that this is an ok thing to do. Sure it'll help with disease but if you can change that, you can probably change other things... I'm all for it but I'm like a lung cancer stem cell scientist or something so I'm biased.

yoooo i nut 🥜 errday in my nappie 😶😥 what if i can just make a buncha meees wit my own nut output 🙄🙄🙄🙄🙄🙄

food fur thawd

Definitely wouldn't help with the pressing issue of overpopulation tho if we ever got to the point of standardized use