Tamrac expedition bags have a reputation for being bombproof, and I can attest to that. So far its one of the most durable bags I've taken into the wilderness - note the hydrophobic zippers on the card/film compartment and laptop sleeve. I've looked it over pretty carefully, and I can't find any damage or defects in the bag. It looks brand new.
I was able to fit a full medium format and DSLR kit, harddrives, chargers, accessories, and a 17" laptop with ease - also fits most photo tripods. As far as backpacks go, this is the best "bring everything" one I've ever used. I'm only selling it because I sold my medium format and no longer need the storage.