Vuze or uTorrent - Torrent programs
Little Snitch - Lets you control incoming/outgoing network activity
Handbrake - DVD Ripping
Toast - CD/DVD Burning
GeekTools - Desktop Customization
iWork/Office for Mac - Word processing, presentations, spreadsheets. I prefer iWork.
Senuti - Pulls music from iPod.
Paintbrush - Like MS Paint
Take the time to learn keyboard shortcuts for everything. If you have an iPod, set it up on a Windows computer, Macs lock you to one computer. Play around with Spaces, Hot corners, etc...
Any electronic will fry if you get it wet and let it run. That being said, I dropped an entire vodka-cran on my g4 PBook's keyboard, and it was fine. Some sticky keys but, meh. My homie also had almost an entire handle of vodka spill into his MBook keyboard, and it was also fine after a battery pull and dry.